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Tablet Manufacturer/Distributor: General Pharmaceuticals Ltd. Generic Name: Loratadine 10 mg Tablet
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✅ Description:
Indications
Loratadine pill relieves the symptoms of seasonal allergic rhinitis, perennial allergic rhinitis, and skin allergies, including chronic urticaria, quickly and effectively. It also helps to relieve allergic rhinitis symptoms as sneezing, nasal discharge, itching, ocular irritation, and burning. Oral administration relieves nasal and ocular signs and symptoms quickly.. Loratadine tablet is also indicated in idiopathic urticaria. In children over 2 years Loratadine tablet is indicated for the symptomatic relief of seasonal allergic rhinitis and allergic skin conditions such as urticaria, nettlerash.
Pharmacology
This tablet is a Loratadine preparation. Loratadine is an antiallergic histamine Hr receptor antagonist that is non-sedative. Loratadine is a long-acting tricyclic antihistamine with selective peripheral Hi-receptor antagonistic action but no sedative or anticholinergic properties. It works quickly and lasts a long time, allowing for once-daily administration.
Dosage & Administration
Below 2 years of age: Loratadine tablet is not recommended for use below 2 years of age since safety and efficacy has not been established.
Children 2-12 years: Body weight over 30 kg: one Loratadine tablet once daily, below 30 kg: half Loratadine tablet once daily.
Adults and children over 12 years of age: One Loratadine tablet once daily. It is usually administered in the morning or when symptoms require treatment.
Interactions
There have been no reports of potentially dangerous medication interactions. Loratadine, unlike many other histamine H1 receptor antagonists, has no potentiating effects when combined with alcohol, according to psychomotor performance studies. Concurrent therapy with medicines that inhibit or are processed by hepatic cytochromes P450 3A4 and 2D6 might cause an increase in plasma concentrations of either medication, which can have negative consequences. Both enzymes are inhibited by cimetidine, but P450 3A4 is inhibited by erythromycin or ketoconazole. These medications raise loratadine levels in the blood, but no side effects have been documented.
Contraindications
Loratadine is contraindicated in patients who have shown hypersensitivity or idiosyncrasy to their components.
Side-Effects
During controlled clinical studies the incidence of adverse events, including sedation and anticholinergic effects observed with 10 mg Loratadine was comparable to that observed with placebo. Loratadine's effect on real driving performance, as well as assessments of cognitive and psychomotor functioning, has been found to be comparable to placebo in studies.
Pregnancy & Lactation
There is no experience of the use of Loratadine in human pregnancy. Therefore its use during pregnancy is not advisable. Loratadine is excreted in breast milk in a very small amount. So nursing mothers are advised not to take the drug.
Precautions & Warnings
Caution should be taken in patients with liver impairment or renal insufficiency (eGFR <30 ml/min).
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